Starting an IVF journey is both hopeful and overwhelming. Along with hormonal injections, scans, and procedures, many couples are introduced to new medical terms that sound confusing and intimidating. One such area is genetic testing in IVF, especially PGT-A, PGT-M, and PGT-SR.
Patients often ask:
- Do I really need genetic testing?
- Which PGT test is right for me?
- Is it safe for the embryo?
- Does it improve IVF success rates?
This blog explains everything in simple, patient-friendly language, so you can make informed decisions with confidence. Leading specialists at the Best IVF Centre in Andhra Pradesh recommend personalized genetic testing based on individual medical history not a one-size-fits-all approach.
What Is PGT (Preimplantation Genetic Testing)?
Preimplantation Genetic Testing (PGT) is a technique used during IVF to check embryos for genetic or chromosomal problems before implantation.
Here’s how it works:
- IVF creates embryos in the lab.
- A few cells are carefully taken from each embryo.
- These cells are tested for genetic or chromosomal abnormalities.
- Only healthy embryos are selected for transfer.
PGT helps:
- Improve chances of pregnancy
- Reduce miscarriage risk
- Lower the chance of genetic disorders in babies
At the Best IVF Centre in Andhra Pradesh, advanced labs ensure that embryo biopsy and testing are performed with maximum safety and accuracy.
Why Is Genetic Testing Important in IVF?
Not all embryos are genetically healthy even if they look perfect under a microscope. Chromosomal or genetic issues are a major cause of:
- Repeated IVF failure
- Recurrent miscarriages
- Failed implantation
- Genetic disorders in children
Genetic testing allows doctors to look inside the embryo, not just at its appearance. This scientific insight plays a major role in improving IVF success rates at the Best IVF Centre in Andhra Pradesh.
Understanding the Three Types of PGT
- PGT-A – For chromosome number problems
- PGT-M – For inherited genetic diseases
- PGT-SR – For structural chromosome rearrangements
What Is PGT-A (Preimplantation Genetic Testing for Aneuploidy)?
PGT-A checks whether an embryo has the correct number of chromosomes.
Why Chromosomes Matter
Humans normally have 46 chromosomes. Too many or too few chromosomes (called aneuploidy) can lead to:
- Failed implantation
- Miscarriage
- Conditions like Down syndrome
Who Should Consider PGT-A?
- Women above 35 years
- Couples with repeated IVF failures
- Recurrent pregnancy loss
- Poor embryo implantation history
Benefits of PGT-A
- Higher implantation rates
- Reduced miscarriage risk
- Fewer IVF cycles needed
- Single embryo transfer with confidence
What Is PGT-M (Preimplantation Genetic Testing for Monogenic Disorders)?
PGT-M is used when one or both parents carry a known genetic disease.
What Are Monogenic Disorders?
- Thalassemia
- Sickle cell anemia
- Cystic fibrosis
- Muscular dystrophy
- Certain inherited metabolic disorders
Who Needs PGT-M?
- You or your partner is a genetic carrier
- There is a family history of genetic disease
- You already have a child with a genetic disorder
What Is PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements)?
PGT-SR is designed for people with structural chromosome rearrangements such as translocations and inversions.
PGT-A vs PGT-M vs PGT-SR
| Feature | PGT-A | PGT-M | PGT-SR |
|---|---|---|---|
| Tests for | Chromosome number | Specific genetic disease | Chromosome structure |
| Best for | Age-related IVF failure | Genetic carriers | Recurrent miscarriages |
| Prevents | Miscarriage, implantation failure | Genetic disorders | Unbalanced embryos |
FAQs: PGT-A vs PGT-M vs PGT-SR
- Is PGT mandatory for all IVF patients? – No.
- Can I choose PGT-A without medical issues? – Yes.
- Does PGT detect all genetic problems? – No.
- Is PGT painful? – No.
- Can PGT improve first-time IVF success? – Yes.
- How long does PGT testing take? – 1–2 weeks.
- Is PGT available in Andhra Pradesh? – Yes.
Final Thoughts
Understanding the difference between PGT-A, PGT-M, and PGT-SR empowers you to take control of your IVF journey. Consult the Best IVF Centre in Andhra Pradesh for accurate diagnosis and compassionate care.